Fragrance-free is an increasing trend in personal care products. Consumers gravitate towards these products due to allergies, sensitivities, medical conditions, maintaining a neutral work environment, and avoiding overpowering scents. When these products contain off-odors, they become much more apparent to the consumer since there is no other fragrance to mask them, resulting in complaints and brand damage. This study used thin film-solid phase microextraction (TF-SPME) in a sensory directed analysis (SDA) approach to extract off-odor compounds from fragrance-free, makeup-removing face wipes. Selectable 1D/2Dgas chromatography-olfactometry/mass spectrometry (1D/2DGC-O/MS) enabled the separation of coeluting chromatographic regions and simultaneous detection of off-odor regions of the chromatogram and mass spectra for off-odor compound identification. Identifying off-odor compounds in consumer goods is crucial for the manufacturer to pinpoint the cause, take corrective actions, and maintain brand success.