Figure: Sample Prep Solution system used for the automated determination of THC and metabolites in blood serum. The system consists of a GERSTEL MultiPurpose Sampler (MPS) Dual Head version with SPE option and Evaporation Station (mVAP) used for sample preparation and introduction to the GC/MS system, which can be delivered as part of a complete package solution.

Sample Prep Solution

THC and metabolites in blood serum

The THC Sample Prep Solution enables the determination of THC, the active compound in cannabis, as well as its metabolites in blood serum. This Sample Prep Solution was developed in cooperation with a reputable forensic institute, the Institute of Forensic Medicine at the University of Schleswig-Holstein in Kiel, Germany. A key element in this solution, which can be delivered complete with GC/MS, is the MultiPurpose Sampler (MPS). Following dilution and addition of an internal standard, the complete sample preparation is performed automatically (Solid Phase Extraction, Evaporation and derivatization) including introduction to the GC/MS and determination of the analytes.

Calibration ranges:  
THC 0,7 - 50 ng / mL
THC-OH 0,9 - 50 ng / mL
THC-COOH 7 - 500 ng / mL

 
Benefits of the GERSTEL THC Sample Prep Solution:

Determination of THC and its metabolites THC-OH & THC-COOH in Blood serum

  • Relevant for the evaluation of traffic-related violations
  • Primary metabolite THC-OH indicates recent consumption
  • Secondary metabolite THC-COOH in high concentration indicates regular consumption

Automated quantitative determination of THC, THC-OH & THC-COOH in blood serum

  • Reliable results based on a proven and validated method
  • Quantitative determination over a wide concentration range

Complete solution including methods and detailed description

  • Fast set-up of the system for productive use, no further method development needed

Completely automated sample preparation following dilution and addition of internal standard

  • Improved laboratory safety since less manual handling steps with blood samples are required
  • Reliable and lasting high quality analysis results

Parallel Processing of sample preparation steps during GC/MS analysis

  • Optimized productivity and system utilization: During the ongoing analysis, the next sample is prepared. As soon as the GC/MS is ready, the next sample has been prepared and is ready to be injected.

Upgrade to Opioids and Cocaine Solution (toxicology) available

  • Simple adaptation to future and changing needs
  • Automated determination of morphine, 6-monoacetylmorphine, codeine, dihydrocodeine, cocaine, Benzoylecgonine, methadone, 7-aminoflunitrazepam
  • Determination of a range of drugs and metabolites with a single automated analysis system